Dementia Linked to Carbohydrates

High caloric intake has been associated with an increased risk of cognitive impairment. Total caloric intake is determined by the calories derived from macronutrients. The objective of the study was to investigate the association between percent of daily energy (calories) from macronutrients and incident mild cognitive impairment (MCI) or dementia. Participants were a population-based prospective cohort of elderly persons who were followed over a median 3.7 years (interquartile range, 2.5-3.9) of follow-up. At baseline and every 15 months, participants (median age, 79.5 years) were evaluated using the Clinical Dementia Rating scale, a neurological evaluation, and neuropsychological testing for a diagnosis of MCI, normal cognition, or dementia. Participants also completed a 128-item food-frequency questionnaire at baseline; total daily caloric and macronutrient intakes were calculated using an established database. The percent of total daily energy from protein (% protein), carbohydrate (% carbohydrate), and total fat (% fat) was computed. Among 937 subjects who were cognitively normal at baseline, 200 developed incident MCI or dementia. The risk of MCI or dementia (hazard ratio, [95% confidence interval]) was elevated in subjects with high % carbohydrate (upper quartile: 1.89 [1.17-3.06]; p for trend = 0.004), but was reduced in subjects with high % fat (upper quartile: 0.56 [0.34-0.91]; p for trend = 0.03), and high % protein (upper quartile 0.79 [0.52-1.20]; p for trend = 0.03) in the fully adjusted models. A dietary pattern with relatively high caloric intake from carbohydrates and low caloric intake from fat and proteins may increase the risk of MCI or dementia in elderly persons.

Notes:

Folksonomies: cognition nutrition dementia

Taxonomies:
/health and fitness/disease (0.443608)
/health and fitness/weight loss (0.352421)
/health and fitness/disease/cholesterol (0.329620)

Keywords:
caloric intake (0.932236 (negative:-0.639574)), high caloric intake (0.866407 (negative:-0.773014)), Total caloric intake (0.737412 (negative:-0.285475)), dementia (0.688510 (negative:-0.547661)), low caloric intake (0.685221 (negative:-0.726793)), Clinical Dementia Rating (0.674450 (negative:-0.372415)), total daily caloric (0.656599 (neutral:0.000000)), cognitive impairment (0.654252 (negative:-0.635945)), population-based prospective cohort (0.609070 (neutral:0.000000)), mild cognitive impairment (0.607215 (negative:-0.452656)), elderly persons (0.601258 (negative:-0.726793)), daily energy (0.589952 (neutral:0.000000)), MCI (0.589531 (negative:-0.447763)), Dementia Linked (0.581173 (negative:-0.819235)), 128-item food-frequency questionnaire (0.575184 (neutral:0.000000)), fully adjusted models (0.557714 (neutral:0.000000)), total daily energy (0.550421 (neutral:0.000000)), incident MCI (0.527662 (negative:-0.354686)), Carbohydrates High (0.485946 (negative:-0.819235)), median age (0.476854 (neutral:0.000000)), high % carbohydrate (0.463805 (positive:0.394624)), neuropsychological testing (0.463042 (negative:-0.351432)), macronutrient intakes (0.459997 (neutral:0.000000)), normal cognition (0.455465 (neutral:0.000000)), neurological evaluation (0.453564 (negative:-0.555779)), hazard ratio (0.445086 (negative:-0.332001)), dietary pattern (0.442378 (negative:-0.726793)), high % protein (0.438810 (neutral:0.000000)), baseline (0.431976 (neutral:0.000000))

Entities:
MCI:Company (0.847811 (negative:-0.447763)), Clinical Dementia Rating:PrintMedia (0.575842 (negative:-0.372415)), 79.5 years:Quantity (0.575842 (neutral:0.000000)), 15 months:Quantity (0.575842 (neutral:0.000000)), 3.7 years:Quantity (0.575842 (neutral:0.000000)), 95%:Quantity (0.575842 (neutral:0.000000))

Concepts:
Nutrition (0.961256): dbpedia | freebase | opencyc
Interquartile range (0.696217): dbpedia | freebase
Metabolism (0.680134): dbpedia | freebase
Median (0.662383): dbpedia | freebase
Cognition (0.624079): dbpedia | freebase | opencyc
Quartile (0.596644): dbpedia | freebase
Normal distribution (0.586099): dbpedia | freebase
Glucose (0.568242): dbpedia | freebase | opencyc

 Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia.
Periodicals>Journal Article:  Roberts, Roberts, Geda, Cha, Pankratz, O'Connor, Knopman, Petersen , Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia., J Alzheimers Dis., Retrieved on 2015-04-07
  • Source Material [www.ncbi.nlm.nih.gov]
  • Folksonomies: cognition nutrition


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    04 MAR 2015

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