Your Productive Life is Only as Long as You Retain Your M...

We ught to consider not only that our life is daily wasting away and a smaller part of it is left, but another thing also must be taken into the account, that if a man should live longer, it is quite uncertain whether the understanding will still continue sufficient for the comprehension of things, and retain the power of contemplation which strives to acquire the knowledge of the divine and the human. For if he shall begin to fall into dotage, perspiration and nutrition and imagination and a...

 Vitamin D and Omega-3 Slow Aging

Previously in DO-HEALTH (including all 2,157 participants), we reported that omega-3 alone reduced the rate of infections by 13% (ref. 22) and the rate of falls by 10% (ref. 23), and all three interventions combined showed a significant additive benefit on reducing prefrailty by 39% (ref. 24) and incident invasive cancer by 61% (ref. 25) over a 3-year follow-up. The aim of the DNAm analysis in DO-HEALTH Bio-Age was to assess the effects of the interventions at the molecular level. Three of th...

 Skepticism on Blue Zones

I started getting interested in this topic when I debunked a couple of papers in Nature and Science about extreme ageing in the 2010s. In general, the claims about how long people are living mostly don’t stack up. I’ve tracked down 80% of the people aged over 110 in the world (the other 20% are from countries you can’t meaningfully analyse). Of those, almost none have a birth certificate. In the US there are over 500 of these people; seven have a birth certificate. Even worse, only abou...

 Wealthy Kids Acquire a Taste for Healthier Foods Because ...

But those kids can learn to like [brocolli], eventually: One 1990 study found that kids need to be presented with unknown foods somewhere between eight and 15 times before they come to accept them. This, of course, doesn’t come cheap. Once rejected, a good number of those eight to 15 servings of broccoli (or carrots or whole grains or fish) are going to end up on the floor and then in the garbage. And on top of that, parents need to buy a dependable backup food to have on hand. Who can aff...

 Nicotinamide riboside (NR) Increases NADP

In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage. Studies in mice have shown that boosting the levels of this cell metabolite—known as NAD —can produce multiple health benefits, including resistance to weight gain, improved control of bl...

 Using Feedback to Control Weight

Recent research has shown that exhaust from lungs (part of excretion) is a major factor in weight loss. Burning 10 kg human fat requires inhalation of 29 kg oxygen. This produces 28 kg carbon dioxide and 11 kg water. As food and drinks are temporarily stored in the human stomach and bowels, the body weight is instantaneously increased with the weight of any food or drink consumed. Metabolism is usually divided into catabolism and anabolism, where catabolism is the process of breaking down ...