NgR1 Improves Brain Plasticity in Adult Mice

Experience rearranges anatomical connectivity in the brain, but such plasticity is suppressed in adulthood. We examined the turnover of dendritic spines and axonal varicosities in the somatosensory cortex of mice lacking Nogo Receptor 1 (NgR1). Through adolescence, the anatomy and plasticity of ngr1 null mice are indistinguishable from control, but suppression of turnover after age 26 days fails to occur in ngr1?/? mice. Adolescent anatomical plasticity can be restored to 1-year-old mice by conditional deletion of ngr1. Suppression of anatomical dynamics by NgR1 is cell autonomous and is phenocopied by deletion of Nogo-A ligand. Whisker removal deprives the somatosensory cortex of experience-dependent input and reduces dendritic spine turnover in adult ngr1?/? mice to control levels, while an acutely enriched environment increases dendritic spine dynamics in control mice to the level of ngr1?/? mice in a standard environment. Thus, NgR1 determines the low set point for synaptic turnover in adult cerebral cortex.

Notes:

The plasticity lost from our youth is revived in mice by deletion of Nogo-A ligand.

Folksonomies: plasticity brain plasticity novice mind

Taxonomies:
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/health and fitness/disorders (0.413197)
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Keywords:
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Entities:
cerebral cortex:FieldTerminology (0.855302 (negative:-0.295445)), 26 days:Quantity (0.855302 (neutral:0.000000)), 1-year:Quantity (0.855302 (neutral:0.000000))

Concepts:
Hippocampus (0.972073): dbpedia | freebase | opencyc
Cerebellum (0.966898): dbpedia | freebase | opencyc
Neuron (0.874705): dbpedia | freebase | opencyc
Brain (0.861109): dbpedia | freebase | opencyc
Cerebral cortex (0.820712): dbpedia | freebase
Cerebrum (0.734772): dbpedia | freebase | opencyc
Dendrite (0.730400): dbpedia | freebase | opencyc
Human brain (0.633008): dbpedia | freebase

 Anatomical Plasticity of Adult Brain Is Titrated by Nogo Receptor
Periodicals>Journal Article:  Akbik, Bhagat, Patel, Cafferty, Strittmatter (6 March 2013), Anatomical Plasticity of Adult Brain Is Titrated by Nogo Receptor , Neuron, Volume 77, Issue 5, Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neurobiology, Yale University , Retrieved on 2013-03-22
  • Source Material [www.sciencedirect.com]
  • Folksonomies: brain neurology brain plasticity


    Triples

    22 MAR 2013

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