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Now, the other kind of stress Structural stress from activity that physical activity cause is structural stress. Now, when I was running this morning, for example, my mitochondria were generating all kinds of ATP to fuel my body, but my mitochondria were also spewing out all kinds of reactive oxygen species, which…
There’s a continuing struggle between complexity and robustness in both evolution and human design. A kind of survival imperative, whether in biology, engineering, or business requires that simple, fragile systems become more robust. But the mechanisms to increase robustness will in turn make the system considerably…
hough it’s not easy to pinpoint the causes of the rise in IQ scores, it’s no paradox that a heritable trait can be boosted by changes in the environment. That’s what happened with height, a trait that also is highly heritable and has increased over the decades, and for some of the same reasons: better nutrition and…
It is widely accepted that aging is accompanied by remodelling of the immune system including thymic atrophy and increased frequency of senescent T cells, leading to immune compromise. However, physical activity, which influences immunity but declines dramatically with age, is not considered in this literature. We…
Some time shortly after the invention of the graphical Internet, it became ripely apparent that humanity was fucking itself with its own technology and was on the fast path toward societal morbidity. We maximized energy extraction without perfecting clean use, accelerated manufacturing technologies and global supply…
For one week, political stories are off-topic. Please flag them. Please also flag political threads on non-political stories. For our part, we'll kill such stories and threads when we see them. Then we'll watch together to see what happens. Why? Political conflicts cause harm here. The values of Hacker News are…
Warm-blooded animals have an elaborate physiological control system to maintain a constant body temperature. In man, this temperature is about 37°C. Any significant deviation from this temperature puts stress on the body and makes it difficult to maintain metabolic processes at their normal rates. Why then, during…
Teaching is commonly associated with instruction, yet in evolution, immunology, and neuroscience, instructional theories are largely defunct. We propose a co-immunity theory of teaching, where attempts by a teacher to alter student neuronal structure to accommodate cultural ideas and practices is sort of a reverse to…
The main difference between an instructional system and a selectional system is that the instructional system uses information from the environment to change the properties of the object in question, but a selectional system has a large and varied population of objects, and the ones that are most fit for the…
So, myth one is that humans are evolved to eat meat and that Palaeolithic peoples consumed large quantities of meat. Humans have no known anatomical, physiological, or genetic adaptations to meat consumption. Quite the opposite, we have many adaptations to plant consumption. Take, for example, vitamin C. Carnivores…
We know, historically, that the "walled garden" approach can have benefits during the early adopter phase. AOL's walled garden provided parental controls, security and organization of online content that was useful to introduce the Internet to mass adoption. But, as we know from IBM, AOL, Microsoft, Apple, etc…
News misleads. News leads us to walk around with the completely wrong risk map in our heads. So terrorism is over-rated. Chronic stress is under-rated. The collapse of Lehman Brothers is overrated. Fiscal irresponsibility is under-rated. Astronauts are over-rated. Nurses are under-rated. News is irrelevant. Out of the…
An immune system of enormous complexity is present in all vertebrate animals. When we place a population of lymphocytes from such an animal in appropriate tissue culture fluid, and when we add an antigen, the lymphocytes will produce specific antibody molecules, in the absense of any nerve cells. I find it astonishing…
To choose a rough example, think of a thorn which has stuck in a finger and produces an inflammation and suppuration. Should the thorn be discharged with the pus, then the finger of another individual may be pricked with it, and the disease may be produced a second time. In this case it would not be the disease, not…
These germs of disease have taken toll of humanity since the beginning of things--taken toll of our prehuman ancestors since life began here. But by virtue of this natural selection of our kind we have developed resisting power; to no germs do we succumb without a struggle, and to many--those that cause putrefaction…
In its essence, the theory of natural selection is primarily an attempt to give an account of the probable mechanism of the origin of the adaptations of the organisms to their environment, and only secondarily an attempt to explain evolution at large. Some modem biologists seem to believe that the word 'adaptation'…
I like to think that when Medawar and his colleagues showed that immunological tolerance could be produced experimentally the new immunology was born. This is a science which to me has far greater potentialities both for practical use in medicine and for the better understanding of living process than the classical…
The body has a very ingenious and usually effective system of natural defence against parasites, called the immune system. The immune system is so complicated that it would take a whole book to explain it. Briefly, when it senses a dangerous parasite the body is mobilized to produce special cells, which are carried by…
Touch plays a very special role in the life of young babies. Because it is so well developed at birth, it provides these brand-new arrivals more detailed access to their fascinating new world than any other sense. Touch is obviously essential to babies' sensory-motor development, but it also has a surprisingly potent…
Glover’s findings are supported by research on the effects of pain experienced by infants after birth. Anna Taddio, a pain specialist at the Hospital for Sick Children in Toronto, noticed more than a decade ago that the male infants she treated seemed more sensitive to pain than their female counterparts. This…