Adult Physical Activity Keeps Immune System Young

It is widely accepted that aging is accompanied by remodelling of the immune system including thymic atrophy and increased frequency of senescent T cells, leading to immune compromise. However, physical activity, which influences immunity but declines dramatically with age, is not considered in this literature. We assessed immune profiles in 125 adults (5579 years) who had maintained a high level of physical activity (cycling) for much of their adult lives, 75 age-matched older adults and 55 young adults not involved in regular exercise. The frequency of nave T cells and recent thymic emigrants (RTE) were both higher in cyclists compared with inactive elders, and RTE frequency in cyclists was no different to young adults. Compared with their less active counterparts, the cyclists had significantly higher serum levels of the thymoprotective cytokine IL-7 and lower IL-6, which promotes thymic atrophy. Cyclists also showed additional evidence of reduced immunesenescence, namely lower Th17 polarization and higher B regulatory cell frequency than inactive elders. Physical activity did not protect against all aspects of immunesenescence: CD28?veCD57 ve senescent CD8 T-cell frequency did not differ between cyclists and inactive elders. We conclude that many features of immunesenescence may be driven by reduced physical activity with age.

Notes:

Folksonomies: aging longevity physical fitness

Taxonomies:
/health and fitness/disease/aids and hiv (0.441250)
/health and fitness/disease (0.421470)
/food and drink/healthy eating (0.336662)

Keywords:
physical activity (0.945518 (:0.000000)), inactive elders (0.797273 (:0.000000)), Activity Keeps Immune (0.693680 (:0.000000)), thymic atrophy (0.642991 (:0.000000)), regulatory cell frequency (0.618859 (:0.000000)), significantly higher serum (0.613979 (:0.000000)), recent thymic emigrants (0.596978 (:0.000000)), thymoprotective cytokine IL-7 (0.590798 (:0.000000)), reduced physical activity (0.578219 (:0.000000)), young adults (0.577590 (:0.000000)), immune compromise (0.549047 (:0.000000)), RTE frequency (0.538143 (:0.000000)), immune profiles (0.518719 (:0.000000)), T-cell frequency (0.505149 (:0.000000)), cyclists (0.494460 (:0.000000)), nave T cells (0.483955 (:0.000000)), senescent T cells (0.476761 (:0.000000)), active counterparts (0.466392 (:0.000000)), high level (0.464386 (:0.000000)), regular exercise (0.461955 (:0.000000)), adult lives (0.457481 (:0.000000)), reduced immunesenescence (0.457033 (:0.000000)), older adults (0.456047 (:0.000000)), lower IL-6 (0.456016 (:0.000000)), additional evidence (0.448667 (:0.000000)), age (0.356546 (:0.000000)), declines (0.343814 (:0.000000)), immunity (0.339205 (:0.000000)), polarization (0.336535 (:0.000000)), literature (0.329455 (:0.000000)), cycling (0.328749 (:0.000000)), different (0.327667 (:0.000000))

Entities:
RTE:Location (0.513991 (:0.000000)), 79 years:Quantity (0.513991 (:0.000000))

Concepts:
Thymus (0.973269): dbpedia_resource
Immune system (0.928247): dbpedia_resource
Immunology (0.770589): dbpedia_resource
Major histocompatibility complex (0.752864): dbpedia_resource
Antibody (0.750721): dbpedia_resource
White blood cell (0.695925): dbpedia_resource
Immunity (0.694880): dbpedia_resource
Humoral immunity (0.693333): dbpedia_resource

 Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood
Periodicals>Journal Article:  Duggal, Pollock, Lazarus, Harridge, Lord (8 March 2018), Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood, Retrieved on 2018-03-20
  • Source Material [onlinelibrary.wiley.com]
  • Folksonomies: exercise aging longevity


    Schemas

    04 MAR 2015

     Longevity

    How to live longer.
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