Nogo receptor 1 Key to a Plastic Mind

Formation of lasting memories is believed to rely on structural alterations at the synaptic level. We had found that increased neuronal activity down-regulates Nogo receptor-1 (NgR1) in brain regions linked to memory formation and storage, and postulated this to be required for formation of lasting memories. We now show that mice with inducible overexpression of NgR1 in forebrain neurons have normal long-term potentiation and normal 24-h memory, but severely impaired month-long memory in both passive avoidance and swim maze tests. Blocking transgene expression normalizes these memory impairments. Nogo, Lingo-1, Troy, endogenous NgR1, and BDNF mRNA expression levels were not altered by transgene expression, suggesting that the impaired ability to form lasting memories is directly coupled to inability to down-regulate NgR1. Regulation of NgR1 may therefore serve as a key regulator of memory consolidation. Understanding the molecular underpinnings of synaptic rearrangements that carry lasting memories may facilitate development of treatments for memory dysfunction.


NgR1 found to be key in the formation of long-term memories.

Folksonomies: memory plasticity

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Troy:Country (0.797706 (neutral:0.000000))

Memory (0.951229): dbpedia | freebase
Gene expression (0.714045): dbpedia | freebase | opencyc
Amygdala (0.697608): dbpedia | freebase | opencyc
Brain (0.639766): dbpedia | freebase | opencyc
Long-term potentiation (0.633955): dbpedia | freebase
Long-term memory (0.540540): dbpedia | freebase
Hippocampus (0.516722): dbpedia | freebase | opencyc
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 Nogo receptor 1 regulates formation of lasting memories
Periodicals>Journal Article:  Karlén, Karlsson, Mattsson, Lundströmer, Codeluppi, Pham, Bäckman, Ögren, Åberg, Hoffman, Sherling, Lupica, Hoffer, Spenger, Josephson, Brené, Olson (2009 November 13), Nogo receptor 1 regulates formation of lasting memories, Proc Natl Acad Sci U S A., 106(48): 20476–20481, Retrieved on 2013-03-22
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  • Folksonomies: brain memory neurology


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