You Can Choose Your Memories

In the earliest days of research, memory was thought to be populated with socalled engrams, memory traces that were localized in specific parts of the brain. To locate one such engram—for the memory of a maze—psychologist Karl Lashley taught rats to run through a labyrinth. He then cut out various parts of their brain tissue and put them right back into the maze. Though the rats’ motor function declined and some had to hobble or crawl their way woozily through the twists and turns, the ...

 Nogo receptor 1 Key to a Plastic Mind

Formation of lasting memories is believed to rely on structural alterations at the synaptic level. We had found that increased neuronal activity down-regulates Nogo receptor-1 (NgR1) in brain regions linked to memory formation and storage, and postulated this to be required for formation of lasting memories. We now show that mice with inducible overexpression of NgR1 in forebrain neurons have normal long-term potentiation and normal 24-h memory, but severely impaired month-long memory in both...