Genes Associated with Brain Volume
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease1, 2and is reduced in schizophrenia3, major depression4 and mesial temporal lobe epilepsy5. Whereas many brain imaging phenotypes are highly heritable6, 7, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10?16) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10?12). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10?7).
Notes:
SNPs: rs7294919(T;T), rs10784502(C;T), and rs10494373(A;A) tied to brain volume.
Folksonomies: genes genetics iq brain volume
Taxonomies:
/health and fitness/disease (0.554443)
/health and fitness/disorders (0.491957)
/health and fitness/disease/headaches and migraines (0.290259)
Keywords:
Brain Volume SNPs (0.940544 (neutral:0.000000)), mean bilateral hippocampal (0.899677 (neutral:0.000000)), mesial temporal lobe (0.846979 (neutral:0.000000)), human brain structures (0.838854 (negative:-0.364239)), brain imaging phenotypes (0.835917 (positive:0.329843)), new biological mechanisms (0.822964 (negative:-0.364239)), intergenic variant rs7294919 (0.809570 (neutral:0.000000)), genome-wide association meta-analyses (0.808817 (neutral:0.000000)), magnetic resonance imaging (0.793475 (neutral:0.000000)), positional candidate gene (0.790725 (positive:0.240438)), large multinational consortium (0.784998 (neutral:0.000000)), total brain volume (0.783397 (neutral:0.000000)), hippocampal volume (0.653516 (neutral:0.000000)), intracranial volumes (0.644086 (neutral:0.000000)), intracranial volume (0.635014 (neutral:0.000000)), neuropsychiatric illness (0.618199 (negative:-0.364239)), incipient Alzheimer (0.612618 (negative:-0.689959)), genetic variants (0.580140 (negative:-0.364239)), suggestive association (0.576941 (neutral:0.000000)), major depression4 (0.575079 (neutral:0.000000)), small effects (0.567448 (neutral:0.000000)), brain tissue (0.567185 (positive:0.240438)), high costs (0.563892 (neutral:0.000000)), genetic influences (0.562025 (negative:-0.376041)), expression levels (0.550707 (positive:0.240438)), hippocampus (0.382001 (negative:-0.689959)), biomarker (0.381874 (negative:-0.689959)), DDR2 (0.381848 (neutral:0.000000)), Genes (0.356272 (neutral:0.000000)), cognition (0.353330 (negative:-0.364239))
Entities:
brain imaging:FieldTerminology (0.884207 (positive:0.329843)), brain tissue:FieldTerminology (0.783178 (positive:0.240438)), temporal lobe:Anatomy (0.495590 (neutral:0.000000)), Alzheimer:HealthCondition (0.427071 (negative:-0.689959)), HMGA2:City (0.347538 (neutral:0.000000)), gene TESC:Person (0.330773 (positive:0.240438))
Concepts:
Brain (0.983242): dbpedia | freebase | opencyc
Hippocampus (0.696333): dbpedia | freebase | opencyc
Temporal lobe (0.644140): dbpedia | freebase | opencyc
Cerebral cortex (0.631183): dbpedia | freebase
Magnetic resonance imaging (0.520194): dbpedia | freebase | opencyc
DNA (0.515178): website | dbpedia | freebase | yago
Temporal lobe epilepsy (0.464525): dbpedia | freebase
Cerebrum (0.412410): dbpedia | freebase | opencyc
Identification of common variants associated with human hippocampal and intracranial volumesSchemas
Genetic Markers
For holding information on various genetic markers that I might want to research in my genome.
