Periodicals>Journal Article:  Akbik, Bhagat, Patel, Cafferty, Strittmatter (6 March 2013), Anatomical Plasticity of Adult Brain Is Titrated by Nogo Receptor , Neuron, Volume 77, Issue 5, Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neurobiology, Yale University , Retrieved on 2013-03-22
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  • Folksonomies: brain neurology brain plasticity


    22 MAR 2013

     NgR1 Improves Brain Plasticity in Adult Mice

    Experience rearranges anatomical connectivity in the brain, but such plasticity is suppressed in adulthood. We examined the turnover of dendritic spines and axonal varicosities in the somatosensory cortex of mice lacking Nogo Receptor 1 (NgR1). Through adolescence, the anatomy and plasticity of ngr1 null mice are indistinguishable from control, but suppression of turnover after age 26 days fails to occur in ngr1−/− mice. Adolescent anatomical plasticity can be restored to 1-year-old mice ...
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    The plasticity lost from our youth is revived in mice by deletion of Nogo-A ligand.