How Steroids Produce Rage in Users

I pride myself on never losing my cool I've never screamed at anyone I've never gotten physical with anyone but the ideas in my head that tell me to do things tell me to do unspeakable things like what they're unspeakable I'd have to speak them you really want to know Mum I'm also [ __ ] weird so just remember that no we bit most people uhprobably don't have this severity but I'll read a comment on social media directed at me I guess about me um and it's from like you know nameless faceless ...

 The Infection Metaphor

Every age has its signature afflictions. Thus, a bacterial age existed; at the latest, it ended with the discovery of antibiotics. Despite widespread fear of an influenza epidemic, we are not living in a viral age. Thanks to immunological technology, we have already left it behind. From a pathological standpoint, the incipient twenty-first century is determined neither by bacteria nor by viruses, but by neurons. Neurological illnesses such as depression, attention deficit hyperactivity disord...

 Exercise Creates Structural Stress

Now, the other kind of stress Structural stress from activity that physical activity cause is structural stress. Now, when I was running this morning, for example, my mitochondria were generating all kinds of ATP to fuel my body, but my mitochondria were also spewing out all kinds of reactive oxygen species, which cause widespread damage throughout my body. I was getting mutations in my DNA, those that damage is causing my telomeres at the end of my chromosomes to shorten its damaging cells. ...

 Why Humans Evolved to be Active

Humans of all to be much more physically active than our ape ancestors. Typical chimpanzee walks maybe two to three kilometers a day, and they take maybe what, three, 4,000 steps a day. A typical hunter-gatherer takes about 15 to 20,000 steps a day. Per kilo hunter-gatherers spend about twice as much energy per kilo on being physically active per day than our ape cousins. And importantly, that physical activity occurs as we age, right? So Americans are pretty inactive, as we all know. A typ...

 Marketplace of Ideas in COVID Responses

One way of gauging the current diversity of cultures is to consider the range of responses countries made to the COVID-19 pandemic.120 There was, of course, some diversity, from the ultrastrict lockdowns in China to the more moderate response in Sweden. But the range of responses was far more limited than it could have been. For example, both the Moderna and the Pfizer-BioNTech vaccines were designed by mid-January 2020 over the course of a few days.121 Not a single country allowed human chal...

 A 1700s Rich Man in Britain

The best that we have seen so far is a poor guide to what is possible. To get some inkling of this, consider the life of a rich man in Britain in 1700—a man with access to the best food, health care, and luxuries available at the time. For all his advantages, such a man could easily die of smallpox, syphilis, or typhus. If he needed surgery or had a toothache, the treatment would be agonising and carry a significant risk of infection. If he lived in London, the air he breathed would be seve...

 1979 Dystopian Vision That Came True

I HAVE THIS recurring nightmare. Jonas Salk has just announced his cure for polio. A bill is introduced in Congress to require mandatory inoculation of school children under HEW direction. Opposition then appears. Ronald Reagan urges "free choice by parents rather than compulsion by government." Mobil runs advertisements with the headline, "From gas tanks to bloodstreams. Where will government go next?" An associate professor of economics does a study for the American Enterprise Institute dem...

 Seeing Organizations as Biological Systems

There’s a continuing struggle between complexity and robustness in both evolution and human design. A kind of survival imperative, whether in biology, engineering, or business requires that simple, fragile systems become more robust. But the mechanisms to increase robustness will in turn make the system considerably more complex. Furthermore, that additional complexity brings with it its own unanticipated failure modes, which are corrected over time with additional robust mechanisms, which ...

 Exercise Meaningful in Having Good Mental Health

In this cross-sectional study, we analysed data from 1 237 194 people aged 18 years or older in the USA from the 2011, 2013, and 2015 Centers for Disease Control and Prevention Behavioral Risk Factors Surveillance System survey. We compared the number of days of bad self-reported mental health between individuals who exercised and those who did not, using an exact non-parametric matching procedure to balance the two groups in terms of age, race, gender, marital status, income, education l...

 Kayfabe

Although the etymology of the word is a matter of debate, for at least 50 years “kayfabe” has referred to the unspoken contract between wrestlers and spectators: We’ll present you something clearly fake under the insistence that it’s real, and you will experience genuine emotion. Neither party acknowledges the bargain, or else the magic is ruined. [...] The aesthetic of World Wrestling Entertainment seems to be spreading from the ring to the world stage. Ask an average Trump support...