19 MAR 2015 by ideonexus

 The Unmentioned Trade-Offs in Life Extention

Now it is not that the cell biologists can’t point to experiments which seem to fit their views, as is common in natural science. (After all, the Earth’s Moon does indeed have a geocentric orbit.) Good colleagues of mine like Robert Reis are able to produce nematode worms that live ten times longer than their unmutated controls, if they use ingenious genetic and environmental manipulation. But nematodes have well-developed physiological machinery for sustaining states of metabolic arrest,...
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From Michael R. Rose's "Immortalist Fictions and Strategies"

21 JAN 2014 by ideonexus

 Our Works Live On Beyond Us

A few of the results of my activities as a scientist have become embedded in the very texture of the science I tried to serve—this is the immortality that every scientist hopes for. I have enjoyed the privilege, as a university teacher, of being in a position to influence the thought of many hundreds of young people and in them and in their lives I shall continue to live vicariously for a while. All the things I care for will continue for they will be served by those who come after me. I fi...
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Quoting Francis Albert Eley Crew's "The Meaning of Death."

21 JUN 2013 by mxplx

 I am my connectome


We know that each of us is unique, but science has struggled to pinpoint where, precisely, our uniqueness resides. Is it in our genes? The structure of our brains? Our genome may determine our eye color and even aspects of our personality. But our friendships, failures, and passions also shape who we are. The question is: how? Sebastian Seung, a dynamic professor at MIT, is on a quest to discover the biological basis of identity. He believes it lies in the pattern of connections between the brain’s neurons, which change slowly over time as we learn and grow. The connectome, as it’s called, is where our genetic inheritance intersects with our life experience. It’s where nature meets nurture. Seung introduces us to the dedicated researchers who are mapping the brain’s connections, neuron by neuron, synapse by synapse. It is a monumental undertaking—the scientific equivalent of climbing Mount Everest—but if they succeed, it could reveal the basis of personality, intelligence, memory, and perhaps even mental disorders. Many scientists speculate that people with anorexia, autism, and schizophrenia are "wired differently," but nobody knows for sure. The brain’s wiring has never been clearly seen. In sparklingly clear prose, Seung reveals the amazing technological advances that will soon help us map connectomes. He also examines the evidence that these maps will someday allow humans to "upload" their minds into computers, achieving a kind of immortality. Connectome is a mind-bending adventure story, told with great passion and authority. It presents a daring scientific and technological vision for at last understanding what makes us who we are. Welcome to the future of neuroscience

19 JUN 2013 by mxplx

 The answer lies in the cancer

Most cancers are the result of "immortal" cells that have ways of evading this programmed destruction of telomere. Cancer cells use every trick in the book to gain immortality. One of their cleverer maneuvers is to keep the little caps, called telomeres, at the end of their chromosomes long. As a normal cell divides, its telomeres gradually erode, eventually becoming so short and dysfunctional that the cell is marked for death. As harsh as this may sound, it's exactly what should happen; elim...
Folksonomies: immortality
Folksonomies: immortality

Man has always longed to live forever. He has continually pushed the frontiers of science in his attempt to reach this goal.Immortality is the ultimate quest for redemption in humanity. Its universal application transcends time, space, and culture appearing in stories from the Epic of Gilgamesh composed some 4000 plus years ago, to novels of the twenty first century

If you are in good health,you can live to 120 years but not much longer,because at age 120 you reach the hayflick limit -maximum times a cell can divide and make new cells.

Telomere, which protects the end of the chromosome from deterioration, is thought to be the "clock of aging" contained within the human body. Many scientists believe that the limit on lifespan and decline in health is imposed by the gradual shortening of our telomeres that occurs with every cell division. It has been repeatedly demonstrated that a human cell that does not undergo telomere shortening will divide indefinitely and is, by all available measurements, immortal.

Now researchers have discovered the first compound that activates telomerase – an enzyme that lengthens telomeres – in the human body, potentially opening the door to arresting or even reversing the aging process. Human cells can keep living and dividing indefinitely when telomerase is continually present; i.e. the cells become immortal

A natural product derived nutraceutical known as TA-65, was shown to lengthen the shortest telomeres in humans, potentially extending human lifespan and healthspan. Telomerase activation is thought to be a keystone of future regenerative medicine and a necessary condition for clinical immortality. Although TA-65 is probably too weak to completely arrest the aging process, it is the first telomerase activator recognized as safe for human use.

01 JUN 2013 by mxplx

 problem is not technology but your lack of will to adapt

The Day the Earth Stood Still (2008) http://www.imdb.com/title/tt0970416/quotes
Folksonomies: immortality prescience
Folksonomies: immortality prescience

Prof.Barnhardt: There must be alternatives. You must have some technology that could solve our problem.

Klaatu: Your problem is not technology. The problem is you. You lack the will to change.

Prof. Barnhardt: Then help us change.

Klaatu: I cannot change your nature. You treat the world as you treat each other.

Prof.Barnhardt: But every civilization reaches a crisis point eventually.

Klaatu: Most of them don't make it.

Prof. Barnhardt: Yours did. How?

Klaatu: Our sun was dying. We had to evolve in order to survive.

Prof.Barnhardt: So it was only when your world was threated with destruction that you became what you are now.

Klaatu: Yes.

Prof.Barnhardt: Well that's where we are. You say we're on the brink of destruction and you're right. But it's only on the brink that people find the will to change. Only at the precipice do we evolve. This is our moment. Don't take it from us, we are close to an answer.

01 JUN 2013 by mxplx

 "Healthy Aging" is not enough

“The universe is full of magical things, patiently waiting for our wits to grow sharper.” http://www.longecity.org/forum/page/index.html/_/articles/action/brokenportal2010
Folksonomies: science immortality
Folksonomies: science immortality

Achieving indefinite life extension is the most important, urgent, and time-sensitive cause ever undertaken in the history of humanity,Regardless of whether we ultimately find that we can achieve indefinite life extension or not, we need to go all the way and see. Our lives- this amazing shot at this incredible mysterious existence- depend on it. We can not afford to sell ourselves short on this. 

sentiments expressed by proponents of the compression of morbidity, though very noble and well meaning, are misleading and harmful to this cause.

28 MAY 2013 by ideonexus

 Actuarial Escape Velocity

actuarial escape velocity is defined as occurring when a year of medical research adds more than a year’s worth of longevity to the total population. Nothing even close to this has ever been achieved, and emerging signs of an asymptotic curve in progress suggest this velocity may never
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A medical concept, when medical research extends lifespans at a rate of more than one year per one year of research.

19 APR 2013 by ideonexus

 Death is Not Assured

The organic perfectibility or deterioration of the classes of the vegetable, or species of the animal kingdom, may be regarded as one of the general laws of nature. This law extends itself to the human race; and it cannot be doubted that the progress of the sanative art, that the use of more wholesome food and more comfortable habitations, that a mode of life which shall develope the physical powers by exercise, without at the same time impairing them by excess; in fine, that the destruction...
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Through perpetual improvement through the sciences, humans may not ever attain immortality, but we may extend our lives indefinitely.

08 JUN 2012 by ideonexus

 We Cannot Extend Our Lives Forward, but We Can Backwards

The alchemists of past centuries tried hard to make the elixir of life: ... Those efforts were in vain; it is not in our power to obtain the experiences and the views of the future by prolonging our lives forward in this direction. However, it is well possible in a certain sense to prolong our lives backwards by acquiring the experiences of those who existed before us and by learning to know their views as well as if we were their contemporaries. The means for doing this is also an elixir of ...
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By reading the works of previous generations, absorbing their knowledge, we can age ourselves mentally.

12 SEP 2011 by ideonexus

 The Written Word Keeps Asimov Immortal

I'm gradually managing to cram my mind more and more full of things. I've got this beautiful mind and it's going to die, and it'll all be gone. And then I say, not in my case. Every idea I've ever had I've written down, and it's all there on paper. And I won't be gone; it'll be there.
Folksonomies: writing atheism immortality
Folksonomies: writing atheism immortality
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Because, after he dies, everything he knows will be written down.