Neurons Use Viruses to Share Information and Learn

When genes are activated, the instructions encoded within their DNA are first transcribed into a related molecule called RNA. Shepherd’s colleague Elissa Pastuzyn showed that the Arc shells can enclose RNA and move it from one neuron to another. And that’s basically what retroviruses do—they use protein shells to protect their own RNA as it moves between cells in a host. So our neurons use a repurposed viral gene to transmit genetic information between each other in an oddly virus-like...

 Nicotinamide riboside (NR) Increases NADP

In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage. Studies in mice have shown that boosting the levels of this cell metabolite—known as NAD —can produce multiple health benefits, including resistance to weight gain, improved control of bl...

 Using Feedback to Control Weight

Recent research has shown that exhaust from lungs (part of excretion) is a major factor in weight loss. Burning 10 kg human fat requires inhalation of 29 kg oxygen. This produces 28 kg carbon dioxide and 11 kg water. As food and drinks are temporarily stored in the human stomach and bowels, the body weight is instantaneously increased with the weight of any food or drink consumed. Metabolism is usually divided into catabolism and anabolism, where catabolism is the process of breaking down ...

 Exercise Releases Brain-Healthy Proteins

We all know that exercise is important for a strong and healthy body. Less appreciated is that exercise seems also to be important for a strong and healthy mind, boosting memory and learning, while possibly delaying age-related cognitive decline [1]. How is this so? Researchers have assembled a growing body of evidence that suggests skeletal muscle cells secrete proteins and other factors into the blood during exercise that have a regenerative effect on the brain. Now, an NIH-supported study...