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The healthy brain theory suggests that our brains are different from those of other apes not because extrava- gantly large brains helped us to survive or to raise offspring, but because such brains are simply better advertisements of how good our genes are. The more complicated the brain, the easier it is to mess up…
The worlds of academia, high fashion, religion, and modern art produce sublime wonders, and sometimes monstrous absurdities. They can afford such creative freedom because their systems of self-regulation and self-perpetuation are insulated from the mun- dane pragmatics of the outside world. Their autonomy endows them…
She wandered on her own, looking at the portraits. The big crowd scenes were too much for her, like epic movies all jammed into a single frame. The subjects of the portraits, on the other hand, looked at her with expressions she recognized immediately. “I am always me, I am always new, I am always me”—for eight…
The Human Cognome Project was an academic research venture to reverse engineer the human brain, paralleling in many ways the Human Genome Project and its success in deciphering the human genome. The HCP was a multidisciplinary undertaking, relevant to biology, neuroscience, psychology, cognitive science, artificial…
Even today a good many distinguished minds seem unable to accept or even to understand that from a source of noise natural selection could quite unaided have drawn all the music of the biosphere. Indeed natural selection operates upon the products of chance and knows no other nourishment; but it operates in a domain…
Fossil bones and footsteps and ruined homes are the solid facts of history, but the surest hints, the most enduring signs, lie in those miniscule genes. For a moment we protect them with our lives, then like relay runners with a baton, we pass them on to be carried by our descendents. There is a poetry in genetics…
'Planning' is simply the result of experience read backward and projected into the future. To me the 'purposive' action of a beehive is simply the summation and integration of its units, and Natural Selection has put higher and higher premiums on the most 'purposeful' integration. It is the same way (to me) in the…
The genome is not a blueprint for constructing a body; it is a recipe for baking a body. As the hox story illustrates, DNA promoters express themselves in the fourth dimension; their timing is all. A chimp has a different head from a human being not because it has a different blueprint for the head, but because it…
We know that nature invariably uses the same materials in its operations. Its ingeniousness is displayed only in the variation of form. Indeed, as if nature had voluntarily confined itself to using only a few basic units, we observe that it generally causes the same elements to reappear, in the same number, in the…
Genetics has enticed a great many explorers during the past two decades. They have labored with fruit-flies and guinea-pigs, with sweet peas and corn, with thousands of animals and plants in fact, and they have made heredity no longer a mystery but an exact science to be ranked close behind physics and chemistry in…
The messages that DNA molecules contain are all but eternal when seen against the time scale of individual lifetimes. The lifetimes of DNA messages (give or take a few mutations) are measured in units ranging from millions of years to hundreds of millions of years; or, in other words, ranging from 10,000 individual…
Haemoglobin is a very large molecule by ordinary standards, containing about ten thousand atoms, but the chances are that your haemoglobin and mine are identical, and significantly different from that of a pig or horse. You may be impressed by how much human beings differ from one another, but if you were to look into…
For it is not cell nuclei, not even individual chromosomes, but certain parts of certain chromosomes from certain cells that must be isolated and collected in enormous quantities for analysis; that would be the precondition for placing the chemist in such a position as would allow him to analyse [the hereditary…
Wherever we seek to find constancy we discover change. Having looked at the old woodlands in Hutcheson Forest, at Isle Royale, and in the wilderness of the boundary waters, in the land of the moose and the wolf, and having uncovered the histories hidden within the trees and within the muds, we find that nature…
The question of relevance comes before that of truth, because to ask whether a statement is true or false presupposes that it is relevant (so that to try to assert the truth or falsity of an irrelevant statement is a form of confusion)...
In a sense, genetics grew up as an orphan. In the beginning botanists and zoologists were often indifferent and sometimes hostile toward it. 'Genetics deals only with superficial characters', it was often said. Biochemists likewise paid it little heed in its early days. They, especially medical biochemists, knew of…
Knowing what we now know about living systems—how they replicate and how they mutate—we are beginning to know how to control their evolutionary futures. To a considerable extent we now do that with the plants we cultivate and the animals we domesticate. This is, in fact, a standard application of genetics today. We…
The quintessential example of the open ideal showed up in Freeman Dyson’s otherwise wonderful piece about the future of synthetic biology in the New York Review of Books. MIT bioengineer Drew Endy, one of the enfants terribles of synthetic biology, opened his spectacular talk at Sci Foo with a slide of Dyson’s…
When I see the butterfly, I imagine in my mind's eye the extraordinary chemical machinery of life, the winding loom of he DNA, the proteins linking like lock and key, the ceaseless hubbub of molecular commerce that goes on behind the scenes, from egg, to caterpillar, to chrysalis, to adult. Surely, no land of faerie…
Evolution is neither moral nor immoral. It just is, and we make of it what we will. I have tried to show that two things we can make of it are that it’s simple and it’s marvelous. And far from constricting our actions, the study of evolution can liberate our minds. Human beings may be only one small twig on the vast…