Transhumanism in Lovecraft

After what he had told, I could scarcely imagine what profounder secrets he was saving for the morrow; but at last it developed that his trip to Yuggoth and beyond—and my own possible participation in it—was to be the next day’s topic. He must have been amused by the start of horror I gave at hearing a cosmic voyage on my part proposed, for his head wabbled violently when I shewed my fear. Subsequently he spoke very gently of how human beings might accomplish—and several times had accomplished—the seemingly impossible flight across the interstellar void. It seemed that complete human bodies did not indeed make the trip, but that the prodigious surgical, biological, chemical, and mechanical skill of the Outer Ones had found a way to convey human brains without their concomitant physical structure.

There was a harmless way to extract a brain, and a way to keep the organic residue alive during its absence. The bare, compact cerebral matter was then immersed in an occasionally replenished fluid within an ether-tight cylinder of a metal mined in Yuggoth, certain electrodes reaching through and connecting at will with elaborate instruments capable of duplicating the three vital faculties of sight, hearing, and speech. For the winged fungus-beings to carry the brain-cylinders intact through space was an easy matter. Then, on every planet covered by their civilisation, they would find plenty of adjustable faculty-instruments capable of being connected with the encased brains; so that after a little fitting these travelling intelligences could be given a full sensory and articulate life—albeit a bodiless and mechanical one—at each stage of their journeying through and beyond the space-time continuum. It was as simple as carrying a phonograph record about and playing it wherever a phonograph of the corresponding make exists. Of its success there could be no question. Akeley was not afraid. Had it not been brilliantly accomplished again and again?

The Old Ones travel through space via surgical enhancements.