The RDOC Matrix

The RDoC research framework can be considered as a matrix whose rows correspond to specified dimensions of function; these are explicitly termed “Constructs,” i.e., a concept summarizing data about a specified functional dimension of behavior (and implementing genes and circuits) that is subject to continual refinement with advances in science. Constructs represent the fundamental unit of analysis in this system, and it is anticipated that most studies would focus on one construct (or perhaps compare two constructs on relevant measures). Related constructs are grouped into major Domains of functioning, reflecting contemporary thinking about major aspects of motivation, cognition, and social behavior; the five domains are Negative Valence Systems (i.e., systems for aversive motivation), Positive Valence Systems, Cognitive Systems, Systems for Social Processes, and Arousal/Regulatory Systems. The columns of the matrix represent different classes of variables (or units of analysis) used to study the domains/constructs. Seven such classes have been specified; these are genes, molecules, cells, neural circuits, physiology (e.g. cortisol, heart rate, startle reflex), behaviors, and self-reports. Circuits represent the core aspect of these classes of variables – both because they are central to the various biological and behavioral levels of analysis, and because they are used to constrain the number of constructs that are defined. Investigators can select any level of analysis to be the independent variable for classification (or multiple levels in some cases, e.g., behavioral functioning stratified by a genetic polymorphism), and dependent variables can be selected from multiple columns. In addition, since constructs are typically studied in the context of particular scientific paradigms, a column for “paradigms” has been added; obviously, however, paradigms do not represent units of analysis.


The new criteria and paradigm for evaluating mental illness and directing research.

Folksonomies: cognition diagnosis evaluation

/technology and computing/programming languages (0.570206)
/health and fitness/disorders (0.224889)
/technology and computing/software/databases (0.222568)

RDoC research framework (0.946054 (neutral:0.000000)), Positive Valence Systems (0.898871 (neutral:0.000000)), Negative Valence Systems (0.897667 (negative:-0.274313)), particular scientific paradigms (0.879079 (neutral:0.000000)), constructs (0.859853 (positive:0.252559)), (e.g. cortisol, heart rate, startle reflex), behaviors, and self-reports. (0.849882 (neutral:0.000000)), RDOC Matrix (0.771501 (negative:-0.393549)), aversive motivation (0.685973 (negative:-0.357546)), continual refinement (0.685381 (neutral:0.000000)), directing research (0.681000 (negative:-0.393549)), new criteria (0.680187 (negative:-0.393549)), mental illness (0.678178 (negative:-0.393549)), dependent variables (0.664084 (neutral:0.000000)), functional dimension (0.662080 (neutral:0.000000)), neural circuits (0.661774 (neutral:0.000000)), relevant measures (0.652381 (positive:0.252594)), fundamental unit (0.652253 (positive:0.252524)), Arousal/Regulatory Systems (0.652097 (neutral:0.000000)), major Domains (0.649449 (neutral:0.000000)), Cognitive Systems (0.649287 (neutral:0.000000)), major aspects (0.643089 (neutral:0.000000)), Social Processes (0.640016 (neutral:0.000000)), different classes (0.637044 (negative:-0.252596)), social behavior (0.636043 (negative:-0.201966)), genetic polymorphism (0.634724 (neutral:0.000000)), core aspect (0.632904 (neutral:0.000000)), heart rate (0.630810 (neutral:0.000000)), independent variable (0.626224 (neutral:0.000000)), behavioral levels (0.626023 (neutral:0.000000)), multiple columns (0.614706 (neutral:0.000000))

Negative Valence Systems:Company (0.825444 (negative:-0.163412)), Positive Valence Systems:Company (0.480444 (neutral:0.000000)), RDoC:Company (0.469398 (neutral:0.000000)), Systems for Social Processes:Organization (0.429504 (neutral:0.000000)), Arousal/Regulatory Systems:Company (0.384043 (neutral:0.000000)), cortisol:Drug (0.349787 (neutral:0.000000)), heart rate:FieldTerminology (0.322987 (neutral:0.000000))

Psychology (0.984742): dbpedia | freebase | opencyc
Human behavior (0.703934): dbpedia | freebase
Behavior (0.581727): dbpedia | freebase
Paradigm (0.496274): dbpedia | freebase
Social relation (0.467157): dbpedia | freebase
Paradigm shift (0.454769): dbpedia | freebase | yago
Cognition (0.434200): dbpedia | freebase | opencyc
Genetics (0.431796): dbpedia | freebase | opencyc

 NIMH Research Domain Criteria (RDoC)
Electronic/World Wide Web>Internet Article:  NIMH, (June, 2011), NIMH Research Domain Criteria (RDoC), NIMH, Retrieved on 2013-05-07
  • Source Material []
  • Folksonomies: psychology diagnosis mental disorders