The 12-Note Octave is Too Good to be True

[Playing notes on a piano] One... Two... Three... Four... Five... Six... Seven... Eight... Nine... Ten... Eleven... Twelve... 12 different pitches, and then back to where we began. Incredible! Fantastic! The mystical number 12. There are 12 hours in the A.M. and 12 hours in the P.M. The new day begins at 12 midnight. There are 12 months in a year. Both the Western and Chinese Zodiac have 12 signs. Further, the Chinese use a 12-year cycle for reckoning time. There are 12 eggs in a dozen. 12 d...

 Nogo receptor 1 Key to a Plastic Mind

Formation of lasting memories is believed to rely on structural alterations at the synaptic level. We had found that increased neuronal activity down-regulates Nogo receptor-1 (NgR1) in brain regions linked to memory formation and storage, and postulated this to be required for formation of lasting memories. We now show that mice with inducible overexpression of NgR1 in forebrain neurons have normal long-term potentiation and normal 24-h memory, but severely impaired month-long memory in both...