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Cancer, we now know, is a disease caused by the uncontrolled growth of a single cell. This growth is unleashed by mutations—changes in DNA that specifically affect genes that incite unlimited cell growth. In a normal cell, powerful genetic circuits regulate cell division and cell death. In a cancer cell, these…
The body of an animal operates as a society or ecosystem whose individual members are cells, reproducing by cell division and organized into collaborative assemblies or tissues. In our earlier discussion of the maintenance of tissues (Chapter 22), our interests were similar to those of the ecologist: cell births…
Most cancers are the result of "immortal" cells that have ways of evading this programmed destruction of telomere. Cancer cells use every trick in the book to gain immortality. One of their cleverer maneuvers is to keep the little caps, called telomeres, at the end of their chromosomes long. As a normal cell divides…