The Signaling Pathway

In a typical signaling pathway, proteins are continually being modified and demodified. Kinases and phosphatases work ceaselessly like ants in a nest, adding phosphate groups to proteins and removing them again. It seems a pointless exercise, especially when you consider that each cycle of addition and removal costs the cell one molecule of ATP—one unit of precious energy. Indeed, cyclic reactions of this kind were initially labeled “futile.” But the adjective is misleading. The additio...

 The Marvelous Invention of Indian Arithematic

It is India that gave us the ingenious method of expressing all numbers by means of ten symbols, each symbol receiving a value of position as well as an absolute value; a profound and important idea which appears so simple to us now that we ignore its true merit. But its very simplicity and the great ease which it has lent to computations put our arithmetic in the first rank of useful inventions; and we shall appreciate the grandeur of the achievement the more when we remember that it escaped...