Evolution as Cyclical Repetition

If we lapse into thinking of the prebiotic, pre-reproductive world as a sort of featureless chaos of chemicals (like the scattered parts of the notorious jetliner assembled by a windstorm), the problem does look daunting and worse, but if we remind ourselves that the key process in evolution is cyclical repetition (of which genetic replication is just one highly refined and optimized instance), we can begin to see our way to turning the mystery into a puzzle: How did all those seasonal cycles...

 The Signaling Pathway

In a typical signaling pathway, proteins are continually being modified and demodified. Kinases and phosphatases work ceaselessly like ants in a nest, adding phosphate groups to proteins and removing them again. It seems a pointless exercise, especially when you consider that each cycle of addition and removal costs the cell one molecule of ATP—one unit of precious energy. Indeed, cyclic reactions of this kind were initially labeled “futile.” But the adjective is misleading. The additio...