1945 Warning of Bacterial Antibiotic Resistance

But I would like to sound one note of warning. Penicillin is to all intents and purposes non-poisonous so there is no need to worry about giving an overdose and poisoning the patient. There may be a danger, though, in underdosage. It is not difficult to make microbes resistant to penicillin in the laboratory by exposing them to concentrations not sufficient to kill them, and the same thing has occasionally happened in the body. The time may come when penicillin can be bought by anyone in the...

 Antibiotics Evolve Bacteria in the Gut

New antibiotics have been coming out at frequent intervals since then, and bacteria have evolved resistance to just about every one of them. Nowadays, the most ominous example is MRSA (methycillin-resistant Staphylococcus aureus), which has succeeded in making many hospitals positively dangerous places to visit. Another menace is ' C. diff.' ( Clostridium difficile). Here again, we have natural selection favouring strains that are resistant to antibiotics; but the effect is overlain by anothe...