Effects of Caffeine on the Developing Fetus

Caffeine crosses the placenta and may even concentrate in the fetal circulation. Concern about its effect on fetal development stems from animal studies, where it has been found to be teratogenic when fed to pregnant rats in high doses; a dose equivalent to 150 cups of strong coffee per day causes malformations in rodents such as missing limbs and digits. However, caffeine does not appear to be a teratogen in h humans. The average pregnant woman is estimated to consume 144 milligrams per day ...